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Daxon 200mg 6 tabs, Nitazoxanide

THERAPEUTIC INDICATIONS: Acute intestinal amebiasis or amebic dysentery caused by Entamoeba histolytica. Daxon is indicated for the treatment of giardiasis caused by Giardia lamblia.

Helminthiasis: Daxon is an anthelmintic effective against nematodes, cestodes and trematodes, indicated for the treatment of Enterobius vermicularis, Ascaris lumbricoides and Strongyloides stercoralis. Necantor americanus, Ancylostoma duodenale, Trichuris trichiura, Taenia saginata, Taenia solium, Hymenolepis nana and Fasciola hepatica, Isospora beli, Cryptosporidium parvum. Amebic liver abscess.

Daxon is indicated for the treatment of symptomatic trichomoniasis in women and men. In women with confirmed presence of Trichomonas vaginalis in the laboratory. Asymptomatic trichomoniasis, when the body is associated with endocervicitis, cervicitis and cervical erosion.

Pharmacokinetics in Humans: Daxon (nitazoxanide) is rapidly absorbed from the intestinal tract, being rapidly metabolized by oxidation of acetyl chain 2 - (hydroxy-1-N-(5-nitro 2-tiazol/benzamida).

The maximum concentration (Cmax of 1.9 mcg / ml) (Tmax 2-6 hours) Daxon (nitazoxanide) can be detected in blood 2 hours after administration of a single dose of 500 mg. The main metabolite excreted unchanged in urine within 24 hours.

In Trichomonas vaginalis, Giardia lamblia and Entamoeba histolytica, the electron resonance studies have shown that biochemical and pyruvate ferridoxin oxidoreductase (PFOR) and hydrogenase less intensity, reduce ferridoxina, which is oxidized by the nitro group of T position on nitroheterocíclicos as Daxon compounds (nitazoxanide).

In these organisms, Daxon (nitazoxanide) is reduced to a toxic radical in an organelle of carbohydrate metabolism, the hydrogenosome, which contains hydrogenase and PFOR ferridoxina.

CONTRAINDICATIONS: Nitazoxanide is contraindicated in patients with a history of hypersensitivity to the active.

Do not use in children younger than 2 years.

PRECAUTIONS General: Patients with gastrointestinal disorders should take the medication with food, because it can increase your discomfort.

Use in Pregnancy and Lactation: Studies of mutagenicity by the Ames and micronucleus test showed no mutagenic activity of nitazoxanide Daxon.

Reproduction studies in rats and rabbits at doses of 200 and 201 times the usual human dose, respectively, showed no evidence of teratogenicity, embryotoxicity and phototoxicity.

The use of this medicine in pregnancy and lactation is the responsibility of the physician, assessing the risk-benefit ratio.

ADVERSE REACTIONS: The most commonly reported adverse reactions are gastrointestinal tract level, particularly nausea, some 8% of patients, sometimes accompanied by headache, anorexia and occasionally vomiting and nonspecific epigastric distress and abdominal cramps.

This medicine causes change in color of urine. If amber color persists, notify your doctor.

DRUG INTERACTIONS AND OTHER GENDER: The concomitant use of coumarin and warfarin may increase the plasma levels and longer prothrombin time.

CHANGES IN RESULTS OF LABORATORY TESTS: may be an elevation in transaminases, moderate, which resolves after discontinuation of medication.

PRECAUTIONS IN RELATION TO EFFECTS OF CARCINOGENESIS, MUTAGENESIS, Impairment of Fertility: The Ames and micronucleus tests showed no teratogenic effects.

The evidence for the mutagenic effect in Salmonella typhimurium were negative for mutagenic effects.

No carcinogenicity data.

DOSAGE AND ADMINISTRATION: Oral.

Presentation and dosage

Note: Amebiasis (cysts and trophozoites), giardiasis, helminthiasis and trichomoniasis

500 mg tablets

 Dispersible tablet 200 mg

 C Suspension 100 mg / 5 ml

Children 1-4 years

   5 ml q12h x 3 days

Children 5-11 years

  1 tablet every 12 hours x 3 days

 5 to 10 ml x 3 days q12h

Children 12 years and adults

 1 tablet every 12 hours x 3 days

 2 tablets every 12 hours x 3 days

 Note: Fascioliasis or amebic liver abscess

Children 1-4 years

   5 ml every 12 h x 7 days

Children 5-11 years

  1 tablet every 12 hours x 7 days

 5 to 10 ml q12h x 7 days

Children 12 years and adults

 1 tablet every 12 hours x 7 days

 2 tablets every 12 hours x 7 days

The recommended dose weight is 15 mg / kg / day divided in 2 doses for 3 days.

REPRESENTATIONS AND MANAGEMENT Overdosage: It is highly unlikely that this overdose.

If there is, the manifestations are local, at the digestive system.

You can induce vomiting and administer aluminum hydroxide with magnesium.

Name of medicine: Daxon
Patent Medicines: Daxon
Active ingredient: Nitazoxanide
Presentation: Tablets
Concentration: 500 mg
Lab: Columbia
Box with 6 pills
Made in: Mexico